A Histidine pH sensor regulates activation of the Ras ... | 水果好營養
![A Histidine pH sensor regulates activation of the Ras ...](https://i.imgur.com/Dp6k9gg.jpg)
由YVercoulen著作·2017·被引用30次—Thisrevealedthataparticularaminoacid,histidine212,playsakeyroleinactivatingRasGRP1.Histidinescanbeinapositivelychargedorneutralform ...
![A Histidine pH sensor regulates activation of the Ras ...](https://i.imgur.com/Dp6k9gg.jpg)
The comments were:
1) What effect does the local environment (e.g. glutamate cluster, solvent exposure) have on the pKa of HIs 212? Is its pKa likely to be different from the usual solvent-exposed value (ca. 6, which is well below the pH range manipulated in the cell-based experiments) and, if so, how might this relate to the proposed pH-sensor mechanism?
This is an excellent point. In the original version we already made the comparison between RasGRP1 and talin, which both have clusters of glutamate around the Histidine pH sensor.
Since RasGRP1CEC construct has molecular weight of 64 kDa, and 18 histidine residues, NMR approaches would be too ambitious to take. Instead, we used a web server to calculate the estimated pKa of His212 in RasGRP1. We estimated the pKa values of the histidine sidechains in RasGRP1, using continuum electrosta...
A Histidine pH sensor regulates activation of the Ras ... | 水果好營養
A pH | 水果好營養
A pH | 水果好營養
A pH | 水果好營養
Characterizing a Histidine Switch Controlling pH | 水果好營養
Histidine | 水果好營養
The pH sensitivity of histidine | 水果好營養
組胺酸 | 水果好營養
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