Palmitate modulates intracellular signaling | 水果好營養
![Palmitate modulates intracellular signaling](https://i.imgur.com/Dp6k9gg.jpg)
由WGuo著作·2007·被引用283次—Palmitatemodulatesintracellularsignaling,inducesendoplasmicreticulumstress,andcausesapoptosisinmouse3T3-L1andratprimarypreadipocytes·Authors.
![Palmitate modulates intracellular signaling](https://i.imgur.com/Dp6k9gg.jpg)
Although fatty acids enhance preadipocyte differentiation in the presence of adequate hormone cocktails, little is known regarding their effects in the absence of these hormones. We have now shown that palmitate, a common long-chain saturated fatty acid, induced apoptosis in both mouse 3T3-L1 and rat primary preadipocytes grown in a normal serum-containing medium. Treatment of preadipocytes with palmitate induced multiple endoplasmic reticulum (ER) stress responses, evidenced by increased protein content of CHOP and GRP78 and splicing of XBP-1 mRNA, as well as altered phosphorylation of eIF2alpha and increased phosphorylation of JNK and Erk1/2. Intriguingly, palmitate induced an early activation of Akt but diminished both Akt activation and its protein mass after prolonged incubation (>6 h). In association with these changes, palmitate reduced expression of beta-catenin and its downstream target, c-Myc and cyclin...
棕櫚酸 | 水果好營養
palmitate | 水果好營養
Palmitic acid | 水果好營養
Palmitate | 水果好營養
Medical Definition of Palmitate | 水果好營養
Isopropyl Palmitate (IPP) | 原料查詢| P | 水果好營養
Palmitate modulates intracellular signaling | 水果好營養
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